This study demonstrates that the use of calcium channel blockers therapy, compared with placebo therapy (OR, 0.68), β-adrenergic blockers therapy (OR, 0.79), diuretics combined with β-adrenergic blockers therapy (OR, 0.89), angiotensin-converting enzyme inhibitors therapy (OR, 0.92), and diuretics therapy (OR, 0.95), was associated with a lower incidence of stroke events in the patients with hypertension. This evidence concerns the gene ACE and Stroke.