A selective model of postnatal deletion of CRHR1 in the forebrain, introduced by Müller and colleagues, revealed a distinct role of CRH/CRHR1 neuronal pathways involved in behavioural regulation from those regulating HPA axis activity [52], with deletion of CRHR1 in limbic structures leading to aberration of anxiety-like behaviours independent of the HPA axis functioning. Here, CRHR1 is linked to Anxiety.