Some studies showed that actin remodeling may play a part in inactivation of some actin binding proteins such as E-cadherins [48], [49] and gelsolin [50] that have tumor-suppressor functions, and activation of actin signaling pathways that leads to malignant phenotypes such as pathways involving Ras [51] and Src [52] proteins. The gene discussed is SRC; the disease is neoplasm.