However, NF-κB activation was synergistically hyperactivated under co-expression of p22-FLIP with HBx (Figure 2 and 6A) through the potential formation of a ternary complex among HBx, p22-FLIP and NEMO in hepatoma cells (Figure 5C, 5D, and 6C). This evidence concerns the gene NFKB1 and hepatocellular carcinoma.