In our study, mean HS-CRP CSF in bacterial meningitis was 2.22, in aseptic, 1.29 and in normal CSF, 0.68.Therefore HS-CRP CSF is not very useful for differentiating bacterial from aseptic meningitis, but can be useful for differentiating bacterial meningitis from normal CSF. This evidence concerns the gene CRP and aseptic meningitis.