NLRP3 and type 2 diabetes mellitus: During the pathogenesis of T2D, the NLRP3 inflammasome has been proposed to sense and mediate downstream inflammatory events of “glucotoxicity” (Zhou et al., 2010), islet amyloid polypeptide (Masters et al., 2010), lipid intermediates (i.e., ceramides) (Vandanmagsar et al., 2011), and fatty acids (Wen et al., 2011).