BCL2 and cancer: Among several anti-cancer mechanisms of curcumin are the modulation of Bcl-2 family proteins and cellular ROS, inhibition of the NF-κ B survival pathway, and inhibition of cyclooxygenase-2 (Divya and Pillai, 2006; Singh and Khar, 2006; Madden et al., 2009; Pinlaor et al., 2009; Shehzad et al., 2010).