Remarkably, frizzled homolog 2 (FZD2) was overexpressed in nine of the HCC tissues, and pygopus homolog 2 (PYGO2) and split-hand/split-foot malformation 3 (SHFM3) were both downregulated in nine HCC tissues compared to their matched normal tissues. Here, FBXW4 is linked to hepatocellular carcinoma.