ABCC6 and pseudoxanthoma elasticum (inherited or acquired): Concerning the use of the knowledge obtained from these studies in the clinics, the situation is encouraging as in various clinical conditions [carriers of PXE mutations (Köblös et al., 2010; Vanakker et al., 2011) and secondary PXE (Aessopos et al., 1992, 2008)] the increase of the expression of the ABCC6 gene could lead to an improvement of the symptoms.