POMC and myeloid sarcoma: Adrenocorticotropic hormone (ACTH) gel (H.P. Acthar® Gel, 2011), a long-acting formulation of the full sequence ACTH(1–39) that includes other pro-opiomelanocortin (POMC) peptides, is considered an alternative to steroids in treatment of optic neuritis and acute exacerbations of MS, as well as other conditions (H.P. Acthar® Gel, 2011).