For example, in studies on experimental autoimmune encephalomyelitis (EAE, a mouse model for MS), orally administered ACTH induced expression of Treg cells, increased secretion of immunoregulatory IL-4, and decreased IL-17, IL-2, and IFN-γ in CNS lymphocytes (Brod and Hood, 2011), while α-MSH induced T cells to produce regulatory cytokines (Taylor and Kitaichi, 2008). This evidence concerns the gene POMC and myeloid sarcoma.