In a recent GWAS of AD pathology, Kramer et al. [85•] discovered that polymorphisms in RELN were associated with higher burden of neurofibrillary tangles (NFT) among older persons without dementia, and they hypothesized a potential role of reelin in tau phosphorylation and that upregulation of reelin may be a compensatory remedy to tau-related stress. Here, RELN is linked to dementia.