Regarding bone turnover markers secreted by bone cells; s-AP, s-BAP, and s-Scl seem not to differ in T1D compared to controls (Leon et al., 1989; Munoz-Torres et al., 1996; Oz et al., 2006; Hamed et al., 2011; Gennari et al., 2012), and s-TRAP seems in normal value range (Munoz-Torres et al., 1996). Here, ACP5 is linked to type 1 diabetes mellitus.