ACP5 and type 2 diabetes mellitus: S-OC and s-TRAP are likely to be decreased in T2D (Rosato et al., 1998; Achemlal et al., 2005; Dobnig et al., 2006; Oz et al., 2006; Zhou et al., 2010; Garcia-Martin et al., 2012b; Shu et al., 2012; Reyes-Garcia et al., 2013) and s-Scl, which impair bone formation (Manolagas and Almeida, 2007; Gennari et al., 2012), seems increased, suggesting that T2D is in a state of low bone turnover.