The dissociation seen in diabetes, where some markers decrease (both formation markers, such as OC in both T1D and T2D, and resorption markers such as CTX and TRAP in T2D), whereas the remainder do not (e.g., AP) could point to a very specific uncoupling effect on these of factors associated with the disruption in glucose metabolism in diabetes. The gene discussed is CYP27A1; the disease is type 2 diabetes mellitus.