S-BAP have a negative relationship with IGF-1 (Kanazawa et al., 2009a, 2011b), while s-OC is in positive relationship with IGF-1 (Kanazawa et al., 2009a), proposing that IGF-1 is a marker of bone formation in T2D specific to OC. Here, IGF1 is linked to type 2 diabetes mellitus.