The NF-kB family includes several members, RelA, c-Rel, RelB, p50 and p52, all able to regulate, as transcription factors, a number of molecules involved in cancer [19, 20, 21, 22, 23], cellular senescence [24], hypertonic stress [25], immunity [26] as well as host defence against pathogens [27, 28]. The gene discussed is NFKB1; the disease is cancer.