Given the demonstrated role of BRG1 in the repair of UV-induced damage and in the repair of cisplatin cross-links (Kothandapani et al., 2012; Zhao et al., 2009), it is highly likely that there are multiple mechanisms by which SWI/SNF complexes promote enhanced survival of melanocytes and melanoma cells following DNA damage. This evidence concerns the gene SMARCA1 and melanoma.