ML-IAP rescues melanoma viability in MITF-disrupted melanoma cells and can promote survival of malignant cells by intrinsic stress as well as in response to chemotherapeutics and other elicitors of DNA damage (Crnkovic-Mertens et al., 2003; Dynek et al., 2008; Liu et al., 2007). The gene discussed is MITF; the disease is melanoma.