We then analyzed the correlation between miR-221/222 and p27Kip1 mRNA expression, as measured by microarray analysis, in a same dataset of MM patients: we found a significant inverse correlation between miR-221/222 and p27Kip1 mRNA (Pearson product-moment correlation, p<0.05) (Fig 2D). Here, CDKN1B is linked to Miyoshi myopathy.