FSCN1 and esophageal squamous cell carcinoma: miR-145, miR-133a and miR-133b were also revealed to have tumour suppressive effects inhibiting ESCC cell proliferation and invasion via repression of the FSCN1 gene, whereas FSCN1 was known to be involved in the metastasis of multiple tumour types and regulated by a number of miRNAs [78].