CDKN1B and gastric cancer: Similarly, the down-regulation of miR-148a was observed in gastric tumour tissues, with miR-148a acting as a tumour metastasis suppressor in gastric cancer through the repression of the gene ROCK1, which encodes a serine/threonine kinase involved in the regulation of cell proliferation and programmed cell death [85], and through the repression of the p27 or CDKN1B gene, which encodes an inhibitor protein of the cell division cycle [86].