The up-regulation of IL-23 dampened the tumour growth in vitro and in vivo through the inhibition of tumour cell proliferation and the induction of apoptosis, which was found to be associated with the IL-23-induced up-regulation of miR-15a expression and the consequent down-regulation of BCL-2 protein expression in paediatric B-ALL cells [65]. This evidence concerns the gene BCL2 and neoplasm.