J. M. Bravo-San Pedro et al. discuss in the review article entitled “Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies” the role of leucine-rich repeat kinase 2 in autophagy and how the deregulations of this degradative mechanism in cells can be implicated in the PD etiology. Here, LRRK2 is linked to Parkinson disease.