The increase in percentage point of HbA1c was associated with 26% increase in risk of cancer (HR 1.26; 95% CI; 1.03–1.55), and use of insulin was associated with markedly lower cancer risk with multivariable HR 0.17 (95% CI; 0.09–0.32) in insulin-users group as comparing to noninsulin group. The gene discussed is INS; the disease is cancer.