LCN2 and chronic kidney disease: Performance of NGAL as a predictor of AKI in the emergency department (ED) has been examined by Nickolas et al. who measured uNGAL on 635 consecutive ED patients and found that it had excellent sensitivity and specificity (90 and 99% at a 130 mg/g creatinine cutoff), as well as the ability to differentiate between AKI and other causes of elevated creatinine, such as chronic kidney disease and prerenal azotemia [58].