It was therefore proposed that the physiological action of Ang IV was mediated through the tyrosine-kinase cMet receptor whose function overlap with those of Ang IV/AT4, that is, memory facilitation, cerebroprotection, seizure, neurite outgrowth, cerebral blood flow, depression, and Parkinson's and Alzheimer's diseases [22]. Here, AGT is linked to early-onset autosomal dominant Alzheimer disease.