(8) Impressively, Shengmai San can significantly attenuate heat stroke-induced arterial hypotension and cerebral ischemia through inhibition of inducible nitric oxide synthase-(iNOS-) dependent nitric oxide (NO) overproduction in the brain and excessive accumulation of inflammatory cytokines like interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in the peripheral blood stream [28]. Here, NOS2 is linked to brain ischemia.