These findings suggest that the inhibition of mast cell degranulation may be one of the important clinical effects of acupuncture in the early-phase response in allergic rhinitis and that this inhibition may be achieved, in part, by downregulation of proinflammatory neuropeptides such as SP, CGRP, and VIP (which have been shown to promote mast cell degranulation) [26–28]. Here, CALCA is linked to allergic rhinitis.