IL4 and allergic rhinitis: The early-phase allergic response in allergic rhinitis is triggered within minutes of allergen inhalation when IgE antibody, bound to mast cells, recognizes allergens and causes degranulation and release of inflammatory mediators such as histamine, tryptase, leukotrienes, prostaglandin D2, and proinflammatory cytokines such as tumour necrosis factor alpha (TNFα) and interleukin 4 (IL-4) [4].