In a carrageenan-induced paw inflammation rat model, the antioedema effects of electroacupuncture were abolished by various disruptions of the HPA axis including adrenalectomy and antagonizing receptors for corticotropin releasing hormone (CRH), adrenocorticotropic hormone (ACTH), or glucocorticoids [47, 48]. The gene discussed is POMC; the disease is inflammatory response.