(7) Similarly, Morus bombycis Koidzumi (MB) extract significantly decreased the clinical arthritis index and suppressed the expression of cytokines (TNF-α, IL-1β, IL-6), chemokines (MIP-1α, RANTES), and MMPs (MMP-1, MMP-3) in mice with CIA [119]. The gene discussed is IL6; the disease is arthritic joint disease.