HLXL-treated rats with AA showed decreased arthritis scores as well as the levels of proinflammatory cytokines (IL-1β, IL-6, IL-17, TNF-α) [136–138], chemokines (RANTES, MCP-1, MIP-1α, GRO/KC), and MMPs [139]. The gene discussed is CCL3; the disease is arthritic joint disease.