Based on anti-CD31 staining, microvessel density (MVD) in tumor tissue from NS group was 34.4 ± 4.4 mm2/field, whereas that in vitexicaprin-treated group was 10 ± 2.7 mm2/field (P  value = 6.14E − 06; Figure 5(b)), indicating that vitexicarpin significantly inhibited tumor angiogenesis. This evidence concerns the gene PECAM1 and neoplasm.