PTPN11 and central nervous system cancer: In these studies using either cells natively expressing sst1 (C6 glioma cells) or CHO-K1 cells transfected with this receptor, a large multimeric protein complex occurred in proximity of sst1 in resting conditions that, besides the receptor, was composed of the trimeric G-protein, Jak2, SHP2, c-Src, and PTPη [135].