PTPN11 and glioma: However, while SHP2 is widely expressed in gliomas, PTPη expression is rather inconstant (it was detected in about 1/3 of the human glioblastomas analysed, [133]), and the possibility to activate this PTP by SST agonists was proposed to represent a potential molecular determinant to obtain antiproliferative responses in glioblastomas [133].