PROM1 and glioma: In gliomas, antiapoptotic genes, including flip, bcl-2, and bcl-xl, as well as IAP family members (xiap, ciap1, ciap2, naip, and survivin) are found at higher levels in CSCs (CD133+), and this correlates with enhanced drug resistance to different agents including temozolomide, carboplatin, VP16, and Taxol [88].