MAPT and Alzheimer disease: Diagnostic AD biomarkers are important to select population for specific selection criteria (e.g., onsets of cognitive impairment evaluated by neuropsychological testing such as the mini-mental state examination), age grouping population and increasing the statistical power of clinical trials, whereas clinical trial AD biomarkers are evaluating the type of therapeutic intervention (e.g., targeting amyloid, tau, etc.), and the clinical disease stages as well as its time-course changes during progressive pathological features [120].