Other methods have examined the relationship between small-nucleotide polymorphism loci in protein phosphatase B and calcium homeostasis modulator 1 (CALHM1), respectively, with AD quantitative biomarkers such as p-tau and Aβ42 CSF or genome-wide association study with MRI brain structure degeneration localized in temporal, parietal, and hippocampal regions [73–77]. The gene discussed is MAPT; the disease is Alzheimer disease.