In MCI, MRI hippocampal atrophy, tempo-parietal hypo-FDG-PET, CSF Aβ42, t-tau and p-tau, and cortical amyloid deposits [11C]-PIB biomarkers were also shown to be useful for diagnostic enrichment, designed for improving clinical trials modifying drugs therapies for AD [140]. This evidence concerns the gene MAPT and Alzheimer disease.