TARDBP and amyotrophic lateral sclerosis: We previously demonstrated that overexpression of wild-type human TDP-43 under control of a neuronal murine Thy-1.2 promoter leads to a dose-dependent ALS-FTLD-like motor phenotype in two independent mouse lines (TAR4/4 and TAR6/6; hereafter called Wt-TAR4/4 and Wt-TAR6/6) [24].