CD4 and infection: Therefore, we examined the numbers of CD4+ and CD8+ T cells present in the lungs of CBA/J IL-10−/− mice over the course of Mtb infection (Fig. 1g, h) and did not observe any differences between wild-type and IL-10−/− CBA/J mice in CD8+ T cell accumulations at late stages of infection, demonstrating that CD8+ T cell expansions occur independent of IL-10.