The TLR-9 2848 AA genotype is associated with significantly higher expression of TLR-9 and the frequency of intracellular IgM positive B cells in patients with Primary Biliary Cirrhosis [34] whilst the TLR-9 1635G/A polymorphism appears to play a role in the susceptibility to Systemic lupus erythematosus (SLE) in a Chinese population [35]. This evidence concerns the gene CD40LG and primary biliary cholangitis.