MBOAT7 and Hydrocephalus: During the course of this study two other groups independently created mice lacking expression of LPIAT1 and described a severe defect in brain development, with reduced cerebral cortex and hippocampus found in forebrains from LPIAT1−/− E18.5 embryos [5] manifesting to severe hydrocephalus in the knockout mouse, affecting the lateral and third ventricles [16].