In contrast, progressive TB is produced by the intratracheal administration of high infecting dose that ensures bacilli proliferation, formation of granulomas with mild interstitial and perivascular inflammation raising maximal Th-1 protective response at day 21 of infection, followed by progressive bacilli burdens, in coexistence with tissue damage and emergence of Th-2 cells [9], [10]. This evidence concerns the gene NELFCD and Granuloma.