Additionally, the changes associated with increased AST, ALT, SDH, eosinopenia, monocytopenia, neutropenia, in addition to the observed thrombocytopenia, leukopenia, and lymphopenia are associated with HPAI infection when comparing to seasonal and swine influenza, and thus may be considered as part of the clinical profile associated with HPAI. The gene discussed is SORD; the disease is infection.