Here we have identified one new lipopeptide (LP01) from S.epidermidis, one of the most commonly isolated bacterial species from healthy human skin [18], [19], and show that the lipopeptide activates TLR2/CD36-p38 MAPK to induce hBD2 and hBD3 expression, thus enabling the skin to mount an enhanced antimicrobial defense against pathogenic infections. This evidence concerns the gene CD36 and infection.