CCR2 and Increased total eosinophil count: Although we did not detect a significant difference in the expression of IL-22 in the IL-23-injected ears of WT and CCR2−/− mice, we reasoned that a decrease in other Th17 or in Th1 cytokines, or an increase in Th2 cytokines might explain the increased ear swelling and eosinophilia observed in CCR2−/− IL-23-injected mouse skin.