Mice injected intradermally with TSLP [63] or transgenic for keratinocyte-specific TSLP expression [64] display hallmark features of atopic dermatitis, including Th2 cytokine production, localized edema, acanthosis, hyperkeratosis and a dermal mononuclear cell infiltrate rich in eosinophils and mast cells. This evidence concerns the gene TSLP and atopic eczema.