Hyperlipidemia (higher levels of serum TG, TC and LDL and lower level of HDL), increased inflammation reaction (increasing levels of IL-6, TNF-αand NF-κB) and apoptosis (higher levels of caspase-3, Bax, higher ratio of Bax/Bcl-2 and histologic evidence) in placentas were found in apoE−/− mice as well. The gene discussed is NFKB1; the disease is hyperlipidemia.