ROS1 and cancer: For the 11 C-oncogenes with deletions in their corresponding cancer types, four genes (ERG, TMPRSS2, ROS1 and GOPC) can create oncogenic fusion genes (ERG-TMPRSS2 and ROS1-GOPC), and deletions in another four (CD74, BCL2, TRIM33 and ETV6) can lead to fusion oncogenes by translocation, as shown in the Mitelman Database of Chromosome Aberrations in Cancer (http://cgap.nci.nih.gov/Chromosomes/Mitelman) and previous studies [20], [31].