HSPA5 and GNE myopathy: Immunofluorescence study showed that calnexin (Fig. 1b1), calreticulin (Fig. 1b3), GRP94 (Fig. 1c1), GRP78 (Fig. 1d1) were expressed in the muscle tissues of GNE myopathy patients whereas, normal control exhibited no immunoreactivity for these molecules (Fig. 1b2, b4, c2, and d2).