NFKB1 and neoplasm: Having the dual functions of both DNA repair and redox activity, it is not only responsible for repairing DNA AP sites caused by oxidative and alkylation damage in order to maintain genomic integrity [42], but also functions as a redox factor regulating the DNA binding activity of transcription factors such as p53, NF-κB and AP-1 that play crucial roles in suppression of carcinogenesis and tumor progression [43], [44].