We here extend these observations and provide evidence that hepatic methionine homeostasis is conserved in C57BL/6N mice on a HF diet based on a PPARα-mediated downregulation of the hepatic transsulfuration pathway and an enhanced Hcy remethylation capacity associated with an elevated taurine production despite repression of hepatic transsulfuration (Fig. 8). Here, PPARA is linked to hydrops fetalis.