AKT1 and nasopharyngeal carcinoma: While our results indicate that SPLUNC1-mediated suppression of miR-141 plays a role in PTEN-mediated AKT activation and that loss of SPLUNC1 occurs in later stages of NPC, Chen et al. found that miR-141 was not differentially expressed in a miRNA profile of NPC samples as compared to adjacent normal tissues [38].