Given that BLM is a DNA damage response (DDR) inducer, we first examined both dose- and time-dependent response of the 14-3-3ε stable HCC cells to BLM to determine the maximum DDR, where the DDR-associated composition of the 14-3-3ε interactome in BLM-treated HCC cells was profiled/determined. The gene discussed is BLM; the disease is hepatocellular carcinoma.