YWHAE and Bloom syndrome: We therefore conservatively considered three times of the average RSD or greater than 36% as the threshold for distinguishing BLM-induced 14-3-3ε interacting proteins, i.e., when the abundance of individual proteins around the bait 14-3-3ε is enriched by 40% or L/H≥1.40 in the immunoprecipitate pulled down from BLM-treated cells, it could be considered as a putative 14-3-3ε interactor.