YWHAE and hepatocellular carcinoma: Given the diverse roles of 14-3-3ε in carcinogenesis, we hypothesize that 14-3-3ε may broadly coordinate multiple biological processes (BPs)/pathways in cellular DNA damage response (DDR), which can be revealed by a systemic dissection of phenotypic 14-3-3ε protein-interacting network (interactome) assembled in HCC cells.