MAP3K7 and hepatocellular carcinoma: Given the known role of TAK1 in promoting the survival of the cells exposed to various stresses and inflammatory cytokines [59], [70], we conclude that the interaction between 14-3-3ε and TAK1 enhanced by a high-dose BLM plays a critical role in inducing apoptosis of the BLM-exposed HCC cells (Figure 7).