It is interesting to note that all the eight primary microcephaly (MCPH) genes such as MCPH1, WDR62 (WD repeat domain 62), CDK5RAP2 (cyclin-dependent kinase 5 regulatory associated protein 2), CEP152 (centrosomal protein 152 kDa), ASPM (abnormal spindle-like, microcephaly-associated protein), CENPJ (centromeric protein J), STIL (SCL/TAL1-interrupting locus) and CEP135 (centrosomal protein 135 kDa) are centrosomal proteins [49]–[52]. This evidence concerns the gene CDK5RAP2 and Primary microcephaly.