At day 1, MI results in a significant leukocytosis with increases in circulating CD11b + Ly6G + neutrophils and CD11b + CD115 + Ly6G- monocytes (P < 0.001) in comparison to non-operated and sham-operated animals (Fig. 1d, e). The gene discussed is ITGAM; the disease is Increased total leukocyte count.