HIF1A and cancer: It is more important to promote coupling of glycolysis to GO (which in turn would eventually result in decreased glycolysis, by decreasing the activity of pro-glycolytic transcription factors, like HIF1α) as this is the strategy that would re-activate the suppressed mitochondria-dependent apoptosis just in cancer cells as opposed to inducing energy starvation and cell death in all tissues utilizing glycolysis for energy production.