For example, chronic myelogenous leukemia (CML) cells dependence on BCR-ABL tyrosine kinase is induced by a chromosomal translocation only in the malignant cells (Rowley, 1973), making Gleevec a selective and effective treatment for CML (Kamb et al., 2007). Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.