Mutations in the genes for IDH (an enzyme that catalyzes the decarboxylation of isocitrate to αKG) have been described in GBM (Dang et al., 2009; Thompson, 2009) and these mutations could result in activation of HIF1α, in part by decreasing αKG levels (MacKenzie et al., 2007). This evidence concerns the gene HIF1A and glioblastoma.