MTOR and pituitary gland adenoma: Interestingly, p27Kip1 was shown to be predictive for dual PI3K-mTOR inhibitor sensitivity in a cell-based model of pituitary adenomas from rats with multiple endocrine neoplasia-like syndrom [21] and p27Kip1 expression correlated with rapalog sensitivity in the NCI-60 cell line platform [45].