CD8A and hantavirus infectious disease: Several studies have suggested that the Hantavirus infection could induce a vigorous cellular immune response in humans [13], [14], including an expansion of the number of activated circulating CD8+ T cells [15]–[17], an increase in the CD8+/CD4+ T-cells ratio [16], the infiltration of CD8+ T lymphocytes in the kidney biopsies of PUUV-infected patients [18], and the high frequencies of virus-specific memory CD8+ T lymphocytes that exist for a long time after the HTNV or PUUV infection [19]–[21].