NFE2L2 and Huntington disease: Given that Nrf2 is not only a key regulator for antioxidant system but also an emerging target to counteract mitochondrial dysfunction in many disease models [25], [26], [32]–[34], we investigated whether Nrf2 signaling was compromised in this cell model of HD and found that the presence of mHtt results in defects in Nrf2 signaling.