The flow cytometry finding of skewing towards activation of TFH-cells in all MS subtypes corresponds to results of histopathology studies which have demonstrated the presence of IL21R+ and IL21+CD4+T-cells in both active and chronic lesions [19] and meningeal inflammation with closely associated T- and B-cells in all MS subtypes [10], [46]. This evidence concerns the gene CD4 and myeloid sarcoma.