Several studies did, however, report increased activation of immune cells in peripheral blood from progressive MS patients including changes in surface phenotype [20]–[27] and expression of cytokines [28], [29], the most consistent being increased expression of IL12p40 and decreased expression of IL10 [25], [26], [29]–[32] indicative of a pro-inflammatory bias in progressive MS. The gene discussed is IL10; the disease is myeloid sarcoma.