In fact, B-cells are known to be important for development and sustaining of TFH- and Th17-responses [11], [51], [52] No studies have described DC-SIGN+B-cells and CD83+B-cells in MS, but DC-SIGN+B-cells have been shown to be activated B-cells in humans [53], and in animal studies CD83+B-cells are involved in antigen-specific T- and B-cell interactions [54]. This evidence concerns the gene CD83 and myeloid sarcoma.