In 2010, South Africa renewed its commitment to uphold WHO’s policy on collaborative TB/HIV activities including the three I’s, and increased the CD4 T-cell count threshold for initiation of TB patients on ART from 200 cells/mm3 to 350 cells/mm3[26].Those campaigns greatly increased advocacy for integrated TB/HIV services and necessitated increased collaboration between national, provincial and district health authorities which together could have positively affected TB and HIV service delivery in surveyed facilities. This evidence concerns the gene CD4 and tuberculosis.